Assess. Build. Execute.

The most comprehensive health and performance system available. No black boxes. No guesswork. No fragmented providers.

800+
BIOMARKERS ACROSS 8 SYSTEMS
Phase 01 Assess · 20d
Phase 03 Execute · Ongoing
The 3-Phase System

The process. No black boxes.

01
Assess 20 DAYS

Executive Assessment

The most comprehensive health analysis available. We map your entire system: bloodwork, hormones, gut, toxic exposure, body composition, cardiovascular, neurological. All before we touch a single protocol.

  • Advanced blood panel (300+ markers)
  • Hormone + HPA axis analysis
  • Gut microbiome + GI-MAP
  • Toxic exposure + heavy metals
  • Body composition (DEXA)
  • VO2 max + cardiovascular fitness
Biomarker Distribution 800+ markers across 8 systems
Hormonal
142
Nutrients & Toxins
208
Metabolic
124
Cardiovascular
86
Inflammation
64
02
Build 2 WEEKS

Performance Blueprint

Your data converts into one fully integrated, personalized protocol. Every decision, from your training split to your supplementation to your sleep architecture, is justified by your biology, not a template.

  • Personalized nutrition framework
  • Training periodization
  • Targeted supplementation
  • Advanced therapy planning
  • Sleep + recovery protocol
  • Full written playbook
Protocol Coverage Every system addressed, nothing left to chance
Nutrition
100%
Sleep Architecture
96%
Training
92%
Supplementation
88%
Advanced Therapies
74%
03
Execute ONGOING

Full Implementation

Your dedicated team manages execution and adjusts in real time. You stop coordinating between providers. You just do the work. Quarterly re-testing confirms what's moving and what needs adjusting.

  • Direct Andrew access (Voxer / Signal)
  • Quarterly biomarker re-tests
  • Real-time protocol adjustments
  • Annual comprehensive reassessment
  • Coordinated specialist referrals
  • Member-only resource library
Quarterly Cadence Biology measured, protocol adjusted, repeat
Week 1 Onboard
Month 1 Execute
Month 3 Retest
Month 6 Adjust
Year 1 Reassess
Operating Principles

Four rules every protocol follows.

These aren't slogans. They're the constraints every decision passes through, from your first lab read to your quarterly retest.

01

Measure completely.

If you haven't measured it, you can't optimize it. Assumption is the enemy of progress.

02

Interpret for performance.

"Normal" is an average. Your biology is not average. Every result is read against the high end, not the middle.

03

Build one system.

Nutrition, training, supplementation, therapies, recovery. One integrated protocol. Nothing lost between providers.

04

Adjust from data.

Every protocol shift is traceable to a measurement. Your biology tells us what it needs. We listen.

You can't optimize what you haven't measured. And nobody has ever measured you properly.

Andrew MartinFounder, Second Prime
What We Measure

800+ biomarkers across 8 systems.

A typical annual physical runs 19 biomarkers. A specialist might run 100. Second Prime's assessment runs 800+, across every system that governs how you feel, think, and perform.

Tap any category to see what's actually measured.

0
Metabolic
How well your body handles fuel.
HbA1c · Fasting insulin · HOMA-IR · Leptin · Adiponectin
Tap for detail →
Metabolic
How well your body handles fuel.

Early insulin resistance starts 10–15 years before a diabetes diagnosis. This panel catches it while it's still fully reversible and connects it to the energy crashes, stalled fat loss, and mid-afternoon fog you're actually feeling.

What's on the panel
Fasting insulin · HOMA-IR · Leptin : Adiponectin ratio · 3-day continuous glucose
0
Cardiovascular
The thing that kills most men your age.
ApoB · Lp(a) · LDL-P · Homocysteine · hs-CRP · VO2 max
Tap for detail →
Cardiovascular
The thing that kills most men your age.

Standard cholesterol panels miss the markers that actually predict heart attacks. ApoB, Lp(a), and LDL particle number are the real signal. Most doctors have never run them on you.

What's on the panel
ApoB · Lp(a) · LDL-P · Homocysteine · VO2 max · CAC score
0
Hormonal
The system that drives energy, drive, and recovery.
Total + Free T · Estradiol · DHEA-S · Cortisol AM/PM · IGF-1
Tap for detail →
Hormonal
The system that drives energy, drive, and recovery.

Testosterone is the one you've heard of. It's one of seventeen hormones that determine how you feel, think, and recover. We map the full axis: thyroid, adrenal, gonadal, pituitary.

What's on the panel
Free T · SHBG · Estradiol (sensitive) · DHEA-S · Diurnal cortisol · IGF-1 · Full thyroid
0
Gut & GI
Where systemic inflammation usually starts.
GI-MAP · Zonulin · Calprotectin · SIBO · Food sensitivities
Tap for detail →
Gut & GI
Where systemic inflammation usually starts.

Gut dysfunction drives inflammation, brain fog, fatigue, and autoimmune issues. Most people never get tested because it rarely shows up as "GI symptoms." We look because it's almost always a factor.

What's on the panel
GI-MAP stool panel · Zonulin · Calprotectin · SIBO breath test · Food sensitivity panel
0
Inflammation
The quiet fire aging you from the inside.
hs-CRP · IL-6 · TNF-α · Omega-3 index · Oxidative stress
Tap for detail →
Inflammation
The quiet fire aging you from the inside.

Chronic low-grade inflammation is the common thread behind cardiovascular disease, dementia, metabolic dysfunction, and accelerated aging. If you can't see it, you can't address it.

What's on the panel
hs-CRP · IL-6 · TNF-α · Homocysteine · Oxidative stress · Omega-3 index
0
Nutrients & Toxins
What's missing. What shouldn't be there.
Vitamin D · B12 · Ferritin · Heavy metals · Mycotoxins · Glyphosate
Tap for detail →
Nutrients & Toxins
What's missing. What shouldn't be there.

You've been exposed to more industrial toxins in your lifetime than any prior generation. Heavy metals, mycotoxins, and pesticide residues accumulate. We find them and build the clearance protocol.

What's on the panel
Full micronutrient panel · Heavy metals (blood + hair) · Mycotoxin panel · Glyphosate
0
Body Composition
The scale is the least useful number.
DEXA · Visceral fat · Lean mass · Bone density · RMR
Tap for detail →
Body Composition
The scale is the least useful number.

DEXA separates fat from muscle from bone, flags dangerous visceral fat, and tracks whether you're actually building quality tissue. RMR tells us your real caloric math. Bodyweight alone lies.

What's on the panel
DEXA scan · Visceral fat score · Lean mass index · Bone density · Resting metabolic rate
0
Cognitive & Sleep
Your instrument for making decisions.
Sleep architecture · HRV · Cognitive screen · Reaction time
Tap for detail →
Cognitive & Sleep
Your instrument for making decisions.

Cognitive decline is gradual and invisible until it isn't. Sleep quality, HRV, and reaction time are objective early signals of where your brain and nervous system actually are, not where you think they are.

What's on the panel
Overnight sleep architecture · HRV trend · Cognitive screen · Reaction time battery
A Straight Read on Fit

Where Second Prime works, and where it doesn't.

We'd rather tell you straight than have you sign up for the wrong thing. Here's where this lands and where it doesn't.

This works great for you if
  • You want the full map of your biology, not a sampled read.
  • You're ready to act on data, even when the answer isn't convenient.
  • You want one integrated protocol, not a stack of disconnected providers.
  • You value direct access to the person running the work.
  • You're investing in the next 30 years, not the next 30 days.
This isn't for you if
  • You want a quick fix or a 30-day program.
  • You want supplements pushed with no underlying data.
  • You want a coach who tells you what you want to hear.
  • You're not ready to change what the data tells you needs changing.
  • You want a light-touch coaching engagement.

Start with the assessment. Everything follows from that.

A 30-minute conversation to determine fit. From there, assessment begins within 2 weeks.

Apply

A straight conversation, not a sales process.